Applications of Domino Transformations in Organic Synthesis, by Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois

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By Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois Fürstner, Guido Koch, Gary A. Molander, Ernst Schaumann

The fast speed of evolution in domino, or cascade-based alterations has revolutionized the perform of chemical synthesis for the construction of average items, designed molecules, and pharmaceuticals.


"Science of Synthesis: purposes of Domino adjustments in natural Synthesis" explores the subject completely and systematically, serving because the foundation for useful functions and destiny examine. The 2-volume set provides the state of the art by way of layout, procedure, and experimental techniques, resulting in a number of occasions being comprehensive inside of a unmarried response vessel. The content material is geared up by way of the center form of response used to start up the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 1 covers polyene/cation-pi cyclizations, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.

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Additional info for Applications of Domino Transformations in Organic Synthesis, Volume 1, Edition: Reprint

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4 Prins–Pinacol Rearrangement . . . . . . . . . . . . . . . . . . . . . . . 2 Ring Contractions . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Rearrangement of Epoxides . . . . . . . . . . . . . . . . . . . . . . . . 2 Favorskii Rearrangement and Quasi-Favorskii Rearrangement . . . . . . . . 3 Ring Closures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Induction by an Electrophilic Step .

4 Synthesis of Cyclopentenones . . . . . . . . . . . . . . . . . . . . . . . 5 Acetate Migration and Reaction with ð-Electrophiles . . . . . . . . . . . . 1 Acetate Migration and Reaction with Alkynes . . . . . . . . . . . . . . . 2 Acetate Migration and Reaction with Alkenes . . . . . . . . . . . . . . . 6 Acetate Migration and Ring-Opening Reactions . . . . . . . . . . . . . . 1 Cyclopentannulations .

2 Initiation by a ð-Acid . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Activation of Alkenes . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Activation of Alkynes . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Induction by a Pericyclic Reaction . . . . . . . . . . . . . . . . . . . . . 3 Induction by a Nucleophilic Step . . . . . . . . . . . . . . . . .

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